Cellular and molecular mechanisms underlying learning and memory impairments produced by cannabinoids
by
Sullivan JM
Molecular Neurobiology Laboratory,
ABSTRACT
Why does smoking marijuana impair learning and memory?
Behavioral studies suggest that a disruption of normal hippocampal function
contributes to these deficits. In vitro experiments find that cannabinoid
receptor activation reduces neurotransmitter release below the levels required
to trigger long-term changes in synaptic strength in the hippocampus. Cannabinoids
reduce glutamate release through a G-protein-mediated inhibition of the
calcium channels responsible for neurotransmitter release from hippocampal
neurons. These mechanisms likely play a role in the learning and memory
impairments produced by cannabinoids and by endogenous cannabinoid receptor
ligands.
